教师风采
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个人简介

    主要从事微流控芯片筛选与高选择性多肽分子识别研究。国家级青年人才,主持国家自然科学基金委面上项目,中央军委后保部开放研究项目,北京市自然科学基金项目等。以通讯作者在SCI期刊发表论文40余篇,包括Angew Chem Int Ed、Adv Mater、Chem Sci、ACS Nano、Anal Chem、Lab Chip等。入选北京市优秀人才培养青年拔尖人才及中科院青促会。以第一完成人获中国分析测试协会科学技术(CAIA奖)二等奖。任北京市色谱学会理事。担任JOAT、Micro-Nano Lett、Exploration期刊青年编委。授权发明专利10余项,其中1项已进入临床(体内)应用。


研究领域和方向

1. 靶向分子识别与精准化学测量
2. 微流控芯片高内涵筛选分析
3. 基于多肽分子探针的纳米医学检测
4. 生物分子影像与智能可控生物医用材料

教育背景

2006.09-2011.07,中国科学院化学研究所,分析化学,理学博士;
2002.09-2006.06,北京理工大学,应用化学,理学学士。

工作履历

2019.07至今,北京理工大学,特别研究员
2016.11-2017.12 斯坦福大学,访问学者
2011.08-2019.06,国家纳米科学中心,助理研究员、副研究员

研究成果

1.Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, Weizhi Wang*. Tailored cross-β assemblies establish peptide “Dominos” structures for anchoring undruggable pharmacophores. Angew. Chem. Int. Ed. 2022, 61, e202212527.
2.Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chem. Sci. 2022, 13, 4052.
3.Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘all-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Adv. Mater. 2022, e202207330.
4.Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, Weizhi Wang*. A “cell space station” for spatiotemporal molecular manipulation of immune checkpoint. ACS Nano 2022, 16, 16332.
5.Shang Wu, Limin Zhang, Weizhi Wang*. Screened αhelix peptide inhibitor toward SARS-CoV2 by blocking a Prion-like domain in the receptor binding domain. Anal. Chem. 2022, 94, 11464.
6.Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Anal. Chem. 2021, 93, 8035.
7.Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology related detection. Anal. Chem. 2022, 94, 431.
8.Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Anal. Chem. 2020, 92, 5650.
9.Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Anal. Chem. 2019, 91, 7245.
10.Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, Weizhi Wang*. Controlled recognition and corona formation by cascade micellar nanoprobes: for boosting glioma theranostics. Anal. Chem. 2022, 94, 11118.
11.Yuwei Tian, Limin Zhang, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosens. Bioelectron. 2021, 184, 113235.
12.Mengzhen Li, Minxuan Wang, Lingyun Li, Limin Zhang, Bing Ma*, Weizhi Wang*. A composite peptide-supramolecular microneedle system for melanoma immunotherapy. Nano Res. 2022, e3032.
13.Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang*. Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring. Biomaterials 2019, 188, 96.
14.Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Adv. Mater. 2018, 30, 1800106.
15.Weizhi Wang*, Zhiyuan Hu*. Targeting peptide-based probes for molecular imaging and diagnosis. Adv. Mater. 2019, 31, 1804827.